|An Investigation Into the Effects of Magnesium Sulfate on the Complications of Succinylcholine Administration in Nulliparous Women Undergoing Elective Cesarean Section: A Double-Blind Clinical Trial|
|Davoud Aghamohamadi1, Mehdi Khanbabayi Gol2|
|1Nursing Research Committee of Imam Reza Hospital, Tabriz University of Medical Sciences, Tabriz, Iran
2Department of Anesthesiology, School of Medicine, Imam Reza Medical, Research & Training Hospital, Tabriz University of Medical Sciences
IJWHR 2019; 7: 520-525
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Keywords : Succinylcholine, Fasciculation, Magnesium sulfate
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Objectives: Controlling the complications of anesthetics (e.g., succinylcholine) seems necessary since they are greater for nulliparous women who undergo elective cesarean section (C-section). The present study aimed to investigate the effects of magnesium sulfate on the complications of succinylcholine administration in nulliparous women undergoing elective C-section.
Materials and Methods: This double-blind clinical trial was conducted on 60 nulliparous women during 2012-2013. The women were randomly assigned to A and B groups. Before inducing the rapid anesthesia with succinylcholine, patients in the intervention group received 30 mg/kg of magnesium sulfate within 10 minutes and then the hemodynamic status and the side effects of succinylcholine were recorded in a special form. Statistical tests were performed using repeated-measures ANOVA, chi-square test, and one-way ANOVA tests and the level of significance was determined to be P < 0.05.
Results: There was no significant difference between the two groups in terms of demographic data (P > 0.059). However, the results indicated that there was a significant difference between the 2 groups regarding the myoglobin level (P = 0.010). Contrarily, the results showed that most patients in the intervention (n=23) and control (n=15) groups experienced no or mild and severe fasciculation, respectively (P < 0.001).
Conclusions: In general, magnesium sulfate can greatly control and reduce the complications of succinylcholine administration, including fasciculation.
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