International Journal of Women's Health and Reproduction Sciences

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Oct 2019, Vol 7, Issue 4

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Study Protocol
The Effectiveness of Single-Dose Azithromycin Versus its Combination With Moxifloxacin Based on the Treatment of Chlamydial Cervicitis: A Study Protocol for a Randomized Clinical Trial
Farnaz Mohammadzadeh¹, Mahrokh Dolatian², Masoumeh Jorjani³, Maryam Afrakhteh⁴, Hamid Alavi Majd⁵, Mostafa Qorbani^6,7
¹Department of Midwifery & Reproductive Health, Student Research Committee, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran ²Department of Midwifery & Reproductive Health, Midwifery and Reproductive Health Research Center, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran ³Department of Pharmacology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran ⁴Department of Obstetrics and gynaecology, Tajrish Shohada Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran ⁵Department of Biostatistics, Paramedical School, Shahid Beheshti University of Medical Sciences, Tehran, Iran ⁶Non-communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran ⁷Chronic Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
IJWHR 2019; 7: 442?450 DOI: 10.15296/ijwhr.2019.74 Viewed : 2755 times Downloaded : 4336 times. Keywords : Trial protocol, Azithromycin, Moxifloxacin, Chlamydial cervicitis
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Abstract

Objectives: Chlamydia trachomatis is globally reported as a pathogenic infection and is the most common bacterial cause of sexually transmitted infection (STI) in most countries. In addition, chlamydial cervicitis and the adverse complications of the first line treatment, namely, azithromycin failure are highly prevalent. Thus, the present study will be conducted to determine and compare the effects of single-dose azithromycin and its combination with moxifloxacin based on syndromic and etiologic methods in the diagnosis and treatment of chlamydial cervicitis. Materials and Methods: This is a study protocol for a randomized clinical trial which will be performed at the Women?s Clinics and Health Centers in Amol, Iran during 2018. Further, the study will evaluate women with cervicitis complaints, who have a proven case of chlamydial cervicitis through syndromic or etiologic diagnostic methods and meet the inclusion criteria for the study population. Discussion: To the best of our knowledge, this trial will be the first study to explore the effects of single-dose azithromycin in combination with moxifloxacin in the treatment of chlamydial cervicitis. The results of this trial will further reveal the diagnostic value of syndromic and etiologic methods in the diagnosis of chlamydial cervicitis.