International Journal of Women's Health and Reproduction Sciences

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Jul 2024, Vol 12, Issue 3

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Case Report
Non-endometrioid Synchronized Endometrial and Ovarian Carcinoma: Report of Two Rare Cases
Soheila Aminimoghaddam¹, Elham Saffarieh², Pegah Kamkarfar³, Mahsa Kiani³, Parinaz Hamednasimi³
¹Department of Obstetrics and Gynecology, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran ²Abnormal Uterine Bleeding Center of Semnan University of Medical Sciences, Semnan, Iran ³Endometriosis Research Centers of Iran University of Medical Sciences, Tehran, Iran
DOI: 10.15296/ijwhr.2023.8010 Viewed : 319 times Downloaded : 314 times. Keywords : Papillary serous carcinoma, Clear cell carcinoma, synchronized endometrial, Ovarian cancer
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Abstract

Objectives: Synchronized endometrial and ovarian cancer (SEOC) is a condition in which there is both primary endometrial and primary ovarian cancer at the same time in a patient. These tumors have a better prognosis than metastatic ones. Most of them are diagnosed in the early stages and are low-grade tumors. So differentiation of this kind of rare tumor from others is essential. No adjuvant chemotherapy seems to be reasonable in cases with low-grade tumors both in endometrioid and non-endometrioid types. High-grades tumors have been described less, but, in some studies, genetic mutations were found in these tumors, which have been the basis of targeted therapy after surgery. Case Presentation: In this report, two rare non-endometrioid types of SEOC cases are discussed. The first case is a low-grade papillary serous carcinoma of the ovary and uterus endometrium. In contrast, the second case is a clear cell carcinoma of the ovary and endometrioid adenocarcinoma of the uterus. We also review the literature in this field. Conclusion: We conclude that in these cases, chemotherapy with routine regimens does not seem to be helpful in early stages with low-grade tumors. Also, in high-grade tumors, targeted therapy may be more effective than adjuvant chemotherapy.