International Journal of Women's Health and Reproduction Sciences

Home Aim and Scope Instructions to Authors Editorial Policies Editorial Board Authorship Agreement Form Open Access and Copyright

Jan 2015, Vol 3, Issue 1

CURRENT ISSUE ARCHIVE AHEAD OF PRINT / ACCEPTED ARTICLE MOST VIEWED ARTICLES NEWS RELATED LINKS

Advanced Search

For Author's & Reviewer's

Committee on Publication
Ethics (COPE) Flowchart

Recommendations for the Conduct

COPE: Reviewers

World Association of Medical Editors(WAME)

EQUATOR Resources : Reviewers

Poll

How do you find the scientific quality of the published articles on our web site?

Very good

Good

Fair

Bad

Very bad

Original Article
The Role of CD16+, CD56+, NK (CD16+/CD56+) and B CD20+ Cells in the Outcome of Pregnancy in Women with Recurrent Spontaneous Abortion
Mehri Ghafourian¹, Neda Ayeneh Band², Ailin Fardi Pour², Wesam Kooti³, Masoud Foroutan Rad³, Mina Badiee¹
¹Department of Immunology, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran ²Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran ³Member of Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
IJWHR 2015; 3: 061-066 DOI: 10.15296/ijwhr.2015.10 Viewed : 6433 times Downloaded : 7488 times. Keywords : Recurrent Spontaneous Abortion, B Cells, CD20, NK Cells, Flow Cytometry
Full Text(PDF) \| Related Articles
Abstract

Objectives: Recurrent Spontaneous Abortion (RSA) is the most common complication of pregnancy. It is considered as one of the most important issues of reproduction in the world. RSA is defined as having three or more miscarriages in the first trimester of pregnancy. Increase in peripheral blood lymphocytes may be associated with abortion; therefore,the study was aimed to investigate and compare the peripheral blood CD16+, CD56+, NK(CD16+/CD56+) and B CD20+ cells populations in diagnosis and on pregnancy outcome in women with abortion. Materials and Methods: In this case-control study, 25 non-pregnant women with at least 3 abortions without obvious reason and 25 non-pregnant women with a living child without history of previous abortion participated. Using monoclonal antibodies anti (CD16, CD56 and CD20) and flow cytometry method, the percentage of cells with these markers was determined. Data analysis was performed by with SPSS 15 software and T-test. Results: CD16+, CD56+ and NK (CD16+/CD56+) cells significantly increased in women with RSA compared with control group (P?0.05) but there were no significant differences in the percentage of B CD20+ cells between the experimental and control groups (P>0.05). Conclusion: According to the results of the present study, increased percentage of NK cells may be considered as a risk factor for RSA but involvement and the role of B CD20+ lymphocytes in RSA cannot be confirmed; however, in regard to important role of B and NK cell in the management of the immune responses, more studies are required to understand the behavior of these cells in the different stages of pregnancy more efficiently