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Jan 2017, Vol 5, Issue 1
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Global Prevalence of Helicobacter pylori Infection in Pregnant Women: A Systematic Review and Meta-analysis Study
Milad Azami1, Marzieh Parizad Nasirkandy2, Akram Mansouri 3, Zahra Darvishi4, Shoboo Rahmati1, Ghobad Abangah5, Hamid Reza Dehghan6, Milad Borji1, Shamsi Abbasalizadeh2
1Student Research Committee, Ilam University of Medical Sciences, Ilam, Iran
2Women?s Reproductive Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
3 School of Nursing and Midwifery, Ahvaz Jundishapour University of Medical Science, Ahvaz, Iran
4Clinical Microbiology Research Center, Ilam University of Medical Sciences, Ilam, Iran
5Department of Internal Medicine, Ilam University of Medical Sciences, Ilam, Iran
6Health Technology Assessment Department, Yazd Cardiovascular Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

IJWHR 2017; 5: 30-36

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Keywords : Prevalence, Helicobacter pylori, Pregnant women, Systematic Review, Meta-Analysis
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Objectives: Pregnant women are among the most vulnerable groups for Helicobacter pylori infection. The infection may cause nausea, vomiting, anemia, fetal growth restriction, fetal anomalies and low birth weight of infants. H. pylori prevalence during pregnancy is vary widely between different geographical regions and given the importance of this infection in pregnancy, systematic review and meta-analysis has been done.

Materials and Methods: The current study has been conducted based on PRISMA guideline. The time interval of the investigated studies was from the beginning of 2000 until March 2016. In order to achieve the related literature, databases sources such as Scopus, PubMed, Science Direct, Cochrane, Embase, Springer, Wiley online library, as well as Google Scholar search engine was used. The search was done using Mesh keywords. Furthermore, all the articles that met the inclusion criteria were evaluated. The data has been analyzed using the random-effects models for meta-analysis and the Stata 11.1.

Results: In 24 studies, a total of 19426 pregnant women had been investigated. The worldwide prevalence of H. pylori infection in pregnant women was calculated to be 46% (95% CI: 38-54). The lowest prevalence of H. pylori infection was seen in Europe, 25% (95% CI: 9-40) and the highest prevalence in South America 62% (95% CI: 53-71).


This meta-analysis shows that about half of the pregnant women worldwide are infected with H. pylori and the prevalence of this infection in South America and Africa is far more than other continents.

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Articles by Azami M
Articles by Mansouri A
Articles by Darvishi Z
Articles by Rahmati S
Articles by Abangah G
Articles by Reza Dehghan H
Articles by Borji M
Articles by Abbasalizadeh S


Articles by Milad Azami
Articles by Akram Mansouri
Articles by Zahra Darvishi
Articles by Shoboo Rahmati
Articles by Ghobad Abangah
Articles by Hamid Reza Dehghan
Articles by Milad Borji

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