Materials and Methods: This cross-sectional study was conducted on 547 eligible breastfeeding mothers with infants, aged between 2 and 6 months, referred to health centers in Falavarjan, a city in Iran. Participants were selected randomly. The socio-demographic questionnaire and QOL Inventory of the World Health Organization (WHO) were completed through interview. The multivariate linear regression analysis was carried out to investigate the relationship of QoL with socio-demographic characteristics.

Results: The mean score (standard deviation) of QoL was 67.6 (13.7) from a range between 0 and 100. According to the multivariate linear regression analysis, the variables of mother?s age, spouse?s age and job, economic status, gestational age at delivery, gravidity, tendency towards pregnancy, breastfeeding history, and breastfeeding training had relationship with QoL.

Conclusion: Considering that the effects of socio-demographic factors on QOL in breastfeeding mothers can be moderated, it seems that the QOL of such mothers can be improved through extensive planning and supportive strategies by family and society.