Objectives: The present study aimed to compare the role of the hydroalcoholic extract of Apium graveolens and Cinnamon zeylanicum on metabolically change and ovarian oxidative injury in a rat model of polycystic ovary syndrome (PCOS).

Materials and Methods: In this experimental research, 64 female Wistar rats with breeding were used including the following groups (G): (I) G1: healthy control; (II) G2: PCOS which received no therapy; (III) G3: PCOS + A. graveolens; (IV) G4: A. graveolens; (V) G5: PCOS + C. zeylanicum; (VI) G6: no PCOS + C. zeylanicum; (VII) G7: PCOS + C. zeylanicum and A. graveolens; and (VIII) G8: C. zeylanicum and A. graveolens. The PCOS was induced by a single dose of the intramuscularly injected estradiol valerate (16 mg/kg). After 14 days, the animals were anesthetized, then their plasma samples were used to check the blood sugar (BS), insulin, and lipid profile. The ovaries of the rats were removed and fixed for histopathological assessment. In addition, the oxidative stress marker in ovarian tissue was evaluated.

Results: The levels of BS, insulin, and lipid profile in plasma significantly enhanced in G2 (P < 0.05) while decreasing significantly in the therapy groups, (P < 0.05). Moreover, a significant decline was observed in the serum level of high-density lipoprotein (HDL) in G2 (P < 0.05) while it enhanced significantly in the therapeutic animals (P < 0.05). Furthermore, a negative change was found in the PCOS group on the ovarian tissue. Besides the oxidative stress enhanced in this tissue while in the treated groups this change was improved.

Conclusions: Generally, it was revealed that the extract of A. graveolens and C. zeylanicum had a useful impact on regulating the serum levels of fast blood sugar (FBS), insulin, lipid profile, and oxidative stress markers in the palliation of the PCOS complications.