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Jul 2023, Vol 11, Issue 3
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Original Article
Can Glycosylated Hemoglobin and Fasting Blood Sugar Replace Glucose Challenge Test in Screening for Gestational Diabetes?
Samin Dehghan1, Farima Mohammadianamiri1, Shahla Yazdani2, Hadis Musavi1, Seyed Zahra Bouzari2, Samira Mesbah1, Mohammad Ali Bayani2, Mohammad abedi samakoush3, Zinatossadat Bouzari4, Ellaheh Ebrahim5
1Student Committee Research, Babol University of Medical Sciences, Babol, Iran
2Clinical Research Development Unit of Rouhani Hospital, Department of Internal Medicine, Babol University of Medical Sciences, Babol, Iran
3Department of Internal Medicine, Mazandaran University of Medical Sciences, Sari, Iran
4Infertility and Reproductive Health Research Center, Health Research Institute & Department of Obstetrics & Gynecology, Babol University of Medical Sciences, Babol, Iran
5North Central Texas Community Healthcare clinic, Inc, USA.
#Both authors contributed equally to this paper

IJWHR 2023; 11: 132-137
DOI: 10.15296/ijwhr.2023.23
Viewed : 1056 times
Downloaded : 1279 times.

Keywords : Diabetes, Pregnancy, Glucose challenge test, Glycosylated hemoglobin
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Objectives: The present study aimed to compare the diagnostic values of glycosylated hemoglobin (HbA1c) and fasting blood sugar (FBS) using the glucose challenge test (GCT) in screening for gestational diabetes.

Materials and Methods: A total of 618 women at 24-28 weeks of pregnancy were selected, and their FBS and HbA1c were measured using the GCT. The obtained results were compared in terms of sensitivity, specificity, as well as positive and negative predictive values using the ROC curve.

Results: At the cut-off point of 1.4, sensitivity was 69.74% and specificity was 69.05 for the FBS test; at the cut-off point of 6.6, sensitivity was 90.79% and specificity was 80.95% for the HbA1c test; the area under the ROC curve was 0.925 with a 95% confidence interval (0.979, 0.872).

Conclusion: The diagnostic values of the HbA1c test and GCT were favorable in screening for gestational diabetes; the HbA1c test also showed a high diagnostic value in women with positive OGCT and GCT results.

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Articles by Dehghan S
Articles by Mohammadianamiri F
Articles by Yazdani S
Articles by Musavi H
Articles by Zahra Bouzari S
Articles by Mesbah S
Articles by Ali Bayani M
Articles by abedi Samakoush M
Articles by Bouzari Z
Articles by Ebrahim E


Articles by Samin Dehghan
Articles by Shahla Yazdani
Articles by Hadis Musavi
Articles by Samira Mesbah
Articles by Ellaheh Ebrahim

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