International Journal of Women\'s Health and Reproduction Sciences

Home Aim and Scope Instructions to Authors Editorial Policies Editorial Board Authorship Agreement Form Open Access and Copyright

Jul 2025, Vol 13, Issue 3

CURRENT ISSUE ARCHIVE AHEAD OF PRINT / ACCEPTED ARTICLE MOST VIEWED ARTICLES NEWS RELATED LINKS

Advanced Search

For Author's & Reviewer's

Committee on Publication
Ethics (COPE) Flowchart

Recommendations for the Conduct

COPE: Reviewers

World Association of Medical Editors(WAME)

EQUATOR Resources : Reviewers

Poll

How do you find the scientific quality of the published articles on our web site?

Very good

Good

Fair

Bad

Very bad

Review
The Value of Ophthalmic Artery Doppler Parameters as a Predictive Tool in Preeclamptic Patients: A Systematic Review and Meta-analysis of Diagnostic Test Accuracy
I Wayan Agus Surya Pradnyana¹, Endang Sri Widiyanti², I Gde Arie Kusuma Wijaya³, Made Favian Budi Gunawan¹, I Gusti Ayu Cintya Paramyta¹, Ni Nengah Devianti Wulan Pradnyani¹
¹Faculty of Medicine, Udayana University, Prof. dr. I.G.N.G Ngoerah General Hospital, Denpasar, Bali, Indonesia ²Maternal Fetal Medicine Division, Department of Obstetrics and Gynecology, Udayana University, Prof. dr. I.G.N.G Ngoerah General Hospital, Denpasar, Bali, Indonesia ³Faculty of Medicine, Ganesha University, Buleleng General Hospital, Singaraja, Bali, Indonesia
IJWHR 2025; 13: 096-114 DOI: 10.15296/ijwhr.2025.8854 Viewed : 51 times Downloaded : 28 times. Keywords : Ophthalmic artery, Diagnosis, Doppler, Preeclampsia, Accuracy
Full Text(PDF) \| Related Articles
Abstract

Objectives: Early detection of preeclampsia (PE) is crucial to prevent severe maternal and fetal complications. Ophthalmic artery Doppler (OAD) presents a viable and non-invasive placenta-independent approach, especially in low-resource settings. This study aims to evaluate the diagnostic accuracy of OAD parameters and address the lack of standardized protocols and comparative analyses with other biomarkers. Methods: This study followed PRISMA guidelines. Data on peak ratio (PR), resistance index (RI), and pulsatility index (PI) were extracted from studies comparing PE and normotensive pregnancies. Bivariate models were used for summary ROC curves to estimate pooled sensitivity, specificity, diagnostic odds ratio (DOR), and area under the curve (AUC). All analyses were performed using R Studio. Results: Seventeen studies involving 2699 pregnant women were included. The PR showed a pooled sensitivity of 0.80 (95% CI 0.66–0.89, I² = 0.0%), specificity of 0.92 (95% CI 0.80–0.97, I² = 91.0%), DOR of 48.85 (95% CI 12.79–186.53, I² = 50.5%, P < 0.001), and AUC of 0.911. The RI showed a pooled sensitivity of 0.76 (95% CI 0.68–0.82, I² = 0%), specificity of 0.76 (95% CI 0.57–0.88, I² = 93.2%), DOR of 11.14 (95% CI 6.01–20.64, I² = 35.6%, P < 0.001), and AUC of 0.774. The PI showed a pooled sensitivity of 0.69 (95% CI 0.58–0.78, I² = 75.2%), specificity of 0.86 (95% CI 0.64–0.96, I² = 88.2%), DOR of 12.89 (95% CI 5.40–30.78, I² = 85.2%, P< 0.001), and AUC of 0.768. The pooled analysis of PR, PI, and RI showed that the PE group had MDs of -0.21 (95% CI -0.21; -0.02), -0.36 (95% CI -0.56; -0.15), and -0.06 (95% CI -0.08; -0.03), respectively. Conclusions: The OAD, particularly the PR parameter, demonstrates high diagnostic accuracy, strong sensitivity, and specificity for identifying PE.